博雅計劃—博雅計劃：運動康復學課題：運動員骨軟骨損傷等骨類疾病成因分析及修復治療策略【大學組】

開始日期：

2023年6月10日

專業(yè)方向：

理工

導師：

Armando（帝國理工學院 Imperial College London (IC) 終身教授）

課程周期：

7周在線小組科研+5周論文輔導

語言：

英文

建議學生年級：

大學生

項目產(chǎn)出：

7周在線小組科研學習+5周論文指導學習 學術報告 EI/CPCI/Scopus/ProQuest/Crossref/EBSCO或同等級別索引國際會議全文投遞與發(fā)表指導（共同一作） 結業(yè)證書 成績單

項目介紹：

本項目將使學生了解臨床醫(yī)生目前用于骨軟骨再生的前沿方法。本項目將從肌肉骨骼系統(tǒng)入手，分析肌肉骨骼功能，探究年輕運動員的骨質(zhì)疏松癥、骨關節(jié)炎和主要損傷類型。研究骨骼和軟骨中骨細胞、成骨細胞和破骨細胞在人類衰老中的動態(tài)過程。以此提出血管生成對組織形成和整合的要求，實現(xiàn)骨軟骨組織修復的臨床工具的研發(fā)。并將這種新型治療材料應用到臨床實驗中，帶領學生分析傳統(tǒng)骨軟骨組織置換策略的優(yōu)點和缺點、適合骨軟骨置換的人工組織的臨床要求、植入手術和術后隨訪、植入后恢復日常活動：患者之間的差異等。學生將在項目結束時，提交項目報告，進行成果展示。 個性化研究課題參考： 再生醫(yī)學（心臟病發(fā)作后心臟組織再生的新方法） 健康老齡化和延長壽命（使人體組織恢復活力的策略，有可能活到 150 歲以上嗎？） 組織工程（如何使用智能材料通過誘導干細胞分化為不同譜系來創(chuàng)造新組織） 將合成生物學與再生醫(yī)學相結合（創(chuàng)造可用于創(chuàng)造新器官和組織的新原核生物） This project will expose students to the cutting-edge methods currently used by clinicians for osteochondral replacement, starting with the musculoskeletal system, analyzing musculoskeletal function, and exploring osteoporosis, osteoarthritis, and major injury types in young athletes. The dynamic process of osteocytes, osteoblasts and osteoclasts in bone and cartilage in human aging were studied. Next, the requirements of angiogenesis for tissue formation and integration are proposed, and the development of clinical tools for osteochondral tissue repair is analyzed. By using this therapeutic material to clinical experiments, the professor leads students to analyze the advantages and disadvantages of traditional osteochondral tissue replacement strategies (using tissue from voluntary donors or own patients), clinical requirements for artificial tissue suitable for osteochondral replacement, Implant surgery and postoperative follow-up, return to daily activities after implantation: differences between patients, etc. At the end of the project, students will submit a project report and present their results. Suggested Future Research Fields: Regenerative medicine (i.e. new approaches to regenerate cardiac tissue after heart attack) Healthy aging and increasing lifespan (i.e. Strategies to rejuvenate human tissues. Could it possible to live more than 150 years?) Tissue engineering (i.e. how to use smart materials to create new tissues by inducing the differentiation of stem cells into different lineages) Merging synthetic biology with regenerative medicine (i.e. to create new prokaryotic organisms that can be used to create new organs and tissues)